Article

Stereoselective methyl-swapping demonstrates target specificity of cognitive enhancer

2026-02-07

Abstract excerpt

The Integrated Stress Response (ISR) couples cellular stress sensing to translational control, playing a critical role in the homeostatic regulation of cell health. However, prolonged and unmitigated ISR activation becomes maladaptive and drives the progression of a wide range of pathologies, including cognitive decline. Pharmacological inhibition of the ISR with the small, drug-like molecule ISRIB has proven rema...

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Literature Corpus work: caa30619-f56e-5293-a497-12cb0d819d37
DOI: 10.64898/2026.02.04.700910

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