Article
Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2014
Wortham Noel C, Martinez Magdalena, Gordiyenko Yuliya, Robinson Carol V, Proud Christopher G
Abstract excerpt
Eukaryotic initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor for eIF2 and a critical regulator of protein synthesis, (e.g., as part of the integrated stress response). Certain mutations in the EIF2B genes cause leukoencephalopathy with vanishing white matter (VWM), an often serious neurological disorder. Comprising 5 subunits, α-ε (eIF2Bε being the catalytic one), eIF2B has always been...
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