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Article

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.

Science (New York, N.Y.) - 30 Mar 2018

Tsai Jordan C, Miller-Vedam Lakshmi E, Anand Aditya A, Jaishankar Priyadarshini, Nguyen Henry C, Renslo Adam R, Frost Adam, Walter Peter

Abstract excerpt

Regulation by the integrated stress response (ISR) converges on the phosphorylation of translation initiation factor eIF2 in response to a variety of stresses. Phosphorylation converts eIF2 from a substrate to a competitive inhibitor of its dedicated guanine nucleotide exchange factor, eIF2B, thereby inhibiting translation. ISRIB, a drug-like eIF2B activator, reverses the effects of eIF2 phosphorylation, and in...

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Identifiers

PMID: 29599213
DOI: 10.1126/science.aaq0939
PMCID: PMC6120582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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