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Article

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.

Nature - 7 Dec 2017

Wartewig Tim, Kurgyis Zsuzsanna, Keppler Selina, Pechloff Konstanze, Hameister Erik, Öllinger Rupert, Maresch Roman, Buch Thorsten, Steiger Katja, Winter Christof, Rad Roland, Ruland Jürgen

Abstract excerpt

T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells and are frequently characterized by genetic gain-of-function variants in T cell receptor (TCR) signalling molecules. Although these oncogenic alterations are thought to drive TCR pathways to induce chronic proliferation and cell survival...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Haploinsufficiency

Share to Lymphoma, T-Cell

Share to Programmed Cell Death 1 Receptor

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Share to T-Lymphocytes

Source

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Identifiers

PMID: 29143824
DOI: 10.1038/nature24649
PMCID: PMC5821214

Genes

PDCD1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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