Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rewiring of B cell receptor signaling by Epstein–Barr virus LMP2A

5 Oct 2020

Abstract excerpt

Epstein-Barr virus (EBV) infects human B cells and reprograms them to allow virus replication and persistence. One key viral factor in this process is latent membrane protein 2A (LMP2A), which has been described as a B cell receptor (BCR) mimic promoting malignant transformation. However, how LMP2A signaling contributes to tumorigenesis remains elusive. By comparing LMP2A and BCR signaling in primary human B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eosinophilic Disorders and Syndromes
Share to Lymphoma Diagnosis and Treatment
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33020271
DOI: 10.1073/pnas.2007946117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rewiring of B cell receptor signaling by Epstein–Barr virus LMP2APMID 33020271Read ↗

The effects of the Epstein-Barr virus latent membrane protein 2A on B cell function.Semantic proximity Read ↗

Latent Membrane Protein 1 and the B Lymphocyte-A Complex RelationshipSemantic proximity Read ↗

EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathwaySemantic proximity Read ↗

Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survivalSemantic proximity Read ↗

Latent membrane proteins from EBV differentially target cellular pathways to accelerate MYC-induced lymphomagenesisSemantic proximity Read ↗

Evasion of affinity-based selection in germinal centers by Epstein–Barr virus LMP2ASemantic proximity Read ↗

NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1Semantic proximity Read ↗

Epstein-Barr Virus LMP2A Drives B Cell Development and Survival in the Absence of Normal B Cell Receptor SignalsSemantic proximity Read ↗

A mutation in Epstein-Barr virus LMP2A reveals a role for phospholipase D in B-Cell antigen receptor trafficking.Semantic proximity Read ↗

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.Semantic proximity Read ↗

Decoding critical targets and signaling pathways in EBV-mediated diseases using large language modelsSemantic proximity Read ↗

B-cell receptor signaling as a driver of lymphoma development and evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.