Article

Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J mice

2024-02-24

Abstract excerpt

There are no appropriate mouse models to study the pathophysiology of spontaneous disc herniations and associated pain pathology. We demonstrate that SM/J mice show a high incidence of age-associated lumbar disc herniations with neurovascular innervations. Transcriptomic comparisons of the SM/J annulus fibrosus with human tissues showed shared pathways related to immune cell activation and inflammation. Notably, a...

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Identifiers and source

Literature Corpus work: 2cbdd77d-86aa-52d9-a451-659c0b2f5102
DOI: 10.1101/2024.02.23.581794

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