Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts.

doi:10.1016/j.jaac.2025.04.010

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Article

Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts.

Journal of the American Academy of Child and Adolescent Psychiatry - 1 Feb 2026

Choi Maia, Poore Holly E, Brislin Sarah J, Barr Peter B, Aliev Fazil, Zellers Stephanie, Saunders Gretchen R B, Salvatore Jessica E, Vrieze Scott I, Harden K Paige, Palmer Abraham A, Raevuori Anu, Latvala Antti, Dick Danielle M

Abstract excerpt

OBJECTIVE: Understanding how genetic risk unfolds across development will be important for using genetics to inform prevention and early intervention. The current study leverages information from 5 large datasets to characterize behavioral manifestations of a genetic liability toward externalizing from ages 6 months to 26 years. METHOD: We used polygenic scores (PGS) derived from a multivariate genome-wide...

Topics

Humans
Child
Child, Preschool
Adolescent
Male
Female
Genome-Wide Association Study
Infant
Young Adult
Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Multifactorial Inheritance

Substance-Related Disorders

Phenotype

Cohort Studies

Problem Behavior

Attention Deficit and Disruptive Behavior Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 40280543
DOI: 10.1016/j.jaac.2025.04.010
PMCID: PMC13267360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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