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Article

Child maltreatment as a transdiagnostic risk factor for the externalizing dimension: a Mendelian randomization study.

Molecular psychiatry - 1 Feb 2025

Konzok Julian, Gorski Mathias, Winkler Thomas W, Baumeister Sebastian E, Warrier Varun, Leitzmann Michael F, Baurecht Hansjörg

Abstract excerpt

Observational studies suggest that child maltreatment increases the risk of externalizing spectrum disorders such as attention deficit hyperactivity disorder (ADHD), conduct disorder (CD), antisocial personality disorder (ASPD), and substance use disorder (SUD). Yet, only few of such associations have been investigated by approaches that provide strong evidence for causation, such as Mendelian Randomization (MR)....

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Source

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Identifiers

PMID: 39174650
DOI: 10.1038/s41380-024-02700-8
PMCID: PMC11746131

Genes

CADM2
SEMA6D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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