Article
Child maltreatment as a transdiagnostic risk factor for the externalizing dimension: a Mendelian randomization study.
Molecular psychiatry - 1 Feb 2025
Konzok Julian, Gorski Mathias, Winkler Thomas W, Baumeister Sebastian E, Warrier Varun, Leitzmann Michael F, Baurecht Hansjörg
Abstract excerpt
Observational studies suggest that child maltreatment increases the risk of externalizing spectrum disorders such as attention deficit hyperactivity disorder (ADHD), conduct disorder (CD), antisocial personality disorder (ASPD), and substance use disorder (SUD). Yet, only few of such associations have been investigated by approaches that provide strong evidence for causation, such as Mendelian Randomization (MR)....
Topics
- Humans
- Mendelian Randomization Analysis
- Genome-Wide Association Study
- Child Abuse
- Substance-Related Disorders
- Risk Factors
- Attention Deficit Disorder with Hyperactivity
- Child
- Male
- Polymorphism, Single Nucleotide