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Article

Correlated evolutionary pressure at interacting transcription factors and DNA response elements can guide the rational engineering of DNA binding specificity.

Journal of molecular biology - 15 Jul 2005

Raviscioni Michele, Gu Peili, Sattar Minawar, Cooney Austin J, Lichtarge Olivier

Abstract excerpt

Understanding the molecular mechanisms of the specific interaction between transcription factor proteins and DNA is key to comprehend the regulation of gene expression and to develop technologies to engineer transcription factors. Thus far, although there have been several attempts to elucidate protein-DNA interaction through amino acid-base recognition codes, sequence based profiles, or physical models of...

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Identifiers

PMID: 15946684
DOI: 10.1016/j.jmb.2005.04.054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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