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Article

DNA plasticity is a key determinant of the energetics of binding of Jun-Fos heterodimeric transcription factor to genetic variants of TGACGTCA motif.

Biochemistry - 29 Dec 2009

Seldeen Kenneth L, McDonald Caleb B, Deegan Brian J, Bhat Vikas, Farooq Amjad

Abstract excerpt

The Jun-Fos heterodimeric transcription factor is a target of a diverse array of signaling cascades that initiate at the cell surface and converge in the nucleus and ultimately result in the expression of genes involved in a multitude of cellular processes central to health and disease. Here, using isothermal titration calorimetry in conjunction with circular dichroism, we report the effect of introducing single...

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Identifiers

PMID: 19921846
DOI: 10.1021/bi901392k
PMCID: PMC2807364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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