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The transcriptional regulatory network modulating human trophoblast stem cells to extravillous trophoblast differentiation

12 Feb 2024

Abstract excerpt

During human pregnancy, extravillous trophoblasts play crucial roles in placental invasion into the maternal decidua and spiral artery remodeling. However, regulatory factors and their action mechanisms modulating human extravillous trophoblast specification have been unknown. By analyzing dynamic changes in transcriptome and enhancer profile during human trophoblast stem cell to extravillous trophoblast...

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Share to Epigenetics and DNA Methylation
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PMID: 38346993
DOI: 10.1038/s41467-024-45669-2

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