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Article

Fragmentation of monoclonal antibodies

1 May 2011

Abstract excerpt

Fragmentation is a degradation pathway ubiquitously observed in proteins despite the remarkable stability of peptide bond; proteins differ only by how much and where cleavage occurs. The goal of this review is to summarize reports regarding the non-enzymatic fragmentation of the peptide backbone of monoclonal antibodies (mAbs). The sites in the polypeptide chain susceptible to fragmentation are determined by a...

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Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 21487244
DOI: 10.4161/mabs.3.3.15608

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