Article
High-Throughput Platform to Identify Antibody Conjugation Sites from Antibody-Drug Conjugate Libraries.
Bioconjugate chemistry - 15 Apr 2020
Yamazoe Sayumi, Hogan Jason M, West Sean M, Deng Xiaodi A, Kotapati Srikanth, Shao Xiang, Holder Patrick, Lamba Vandana, Huber Mary, Qiang Cong, Gangwar Sanjeev, Rao Chetana, Dollinger Gavin, Rajpal Arvind, Strop Pavel
Abstract excerpt
Antibody-drug conjugates (ADCs) are a therapeutic modality that traditionally enable the targeted delivery of highly potent cytotoxic agents to specific cells such as tumor cells. More recently, antibodies have been used to deliver molecules such as antibiotics, antigens, and adjuvants to bacteria or specific immune cell subsets. Site-directed mutagenesis of proteins permits more precise control over the site and...
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