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Article

Heterogeneity of monoclonal antibodies.

Journal of pharmaceutical sciences - 1 Jul 2008

Liu Hongcheng, Gaza-Bulseco Georgeen, Faldu Dinesh, Chumsae Chris, Sun Joanne

Abstract excerpt

Heterogeneity of monoclonal antibodies is common due to the various modifications introduced over the lifespan of the molecules from the point of synthesis to the point of complete clearance from the subjects. The vast number of modifications presents great challenge to the thorough characterization of the molecules. This article reviews the current knowledge of enzymatic and nonenzymatic modifications of...

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PMID: 17828757
DOI: 10.1002/jps.21180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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