Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Monoclonal antibody disulfide reduction during manufacturing

18 Apr 2013

Abstract excerpt

Manufacturing-induced disulfide reduction has recently been reported for monoclonal human immunoglobulin gamma (IgG) antibodies, a widely used modality in the biopharmaceutical industry. This effect has been tied to components of the intracellular thioredoxin reduction system that are released upon cell breakage. Here, we describe the effect of process parameters and intrinsic molecule properties on the extent of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Monoclonal and Polyclonal Antibodies Research
Share to Protein purification and stability
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23751615
DOI: 10.4161/mabs.24725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Monoclonal antibody disulfide reduction during manufacturingPMID 23751615Read ↗

Identification and prevention of antibody disulfide bond reduction during cell culture manufacturingSemantic proximity Read ↗

Impact of cell culture on recombinant monoclonal antibody product heterogeneitySemantic proximity Read ↗

Multi Attribute Monitoring Method for Process Development of Engineered Antibody for Site-Specific ConjugationSemantic proximity Read ↗

Advances in recombinant antibody manufacturingSemantic proximity Read ↗

Heterogeneity of monoclonal antibodies.Semantic proximity Read ↗

“Biophysical and Colloidal Properties Govern Anti-Drug Antibody Generation: A Case Study Using the Tumoricidal mAb 4713”Semantic proximity Read ↗

Improving Multispecific Antibody Bioprocesses Through Co-Culture and Column-Based Redox Reactions: Part IISemantic proximity Read ↗

Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process developmentSemantic proximity Read ↗

Biologics Targeting B-cells in Autoimmune Disorders and Manufacturing ConsiderationsSemantic proximity Read ↗

Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability.Semantic proximity Read ↗

Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteinsSemantic proximity Read ↗

Continuous precipitation of IgG from CHO cell culture supernatant in a tubular reactorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.