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Article

An epitope-enriched immunogen expands responses to a conserved viral site

1 Nov 2022

Abstract excerpt

Pathogens evade host humoral responses by accumulating mutations in surface antigens. While variable, there are conserved regions that cannot mutate without compromising fitness. Antibodies targeting these conserved epitopes are often broadly protective but remain minor components of the repertoire. Rational immunogen design leverages a structural understanding of viral antigens to modulate humoral responses to...

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PMID: 36351401
DOI: 10.1016/j.celrep.2022.111628

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