Article

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

2018-09-29

Abstract excerpt

Throughout the last decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g. respiratory syncytial virus (RSV), influenza, dengue and others) have resisted vaccine development efforts, largely due to the failure to induce potent antibody responses targeting conserved epitopes. Deep profiling of human B-cells often reveals potent neutralizing antibodies that emer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 079435b6-4253-5373-9791-d87df7f53350
DOI: 10.1101/430157

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogenDOI 10.1101/430157Read

Optimizing the breadth of SARS-CoV-2-neutralizing antibodies in vivo and in silicoSemantic proximity Read

Systems-Scale Structural Modeling Reveals the Germline Architecture of ImmunodominanceSemantic proximity Read

Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprintingSemantic proximity Read

Sagacious Epitope Selection for Vaccines, and Both Antibody-Based Therapeutics and Diagnostics: Tips From Virology and Oncology<strong> </strong>Semantic proximity Read

One Thousand SARS-CoV-2 Antibody Structures Reveal Convergent Binding and Near-Universal Immune EscapeSemantic proximity Read

Comprehensive profiling of neutralizing polyclonal sera targeting coxsackievirus B3.Semantic proximity Read

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV NeutralizationSemantic proximity Read

A general approach for identifying protein epitopes targeted by antibody repertoires using whole proteomesSemantic proximity Read

Antibody avidity and multi-specificity combined to confer protection against SARS-CoV-2 and resilience against viral escapeSemantic proximity Read

An epitope-enriched immunogen increases site targeting in germinal centersSemantic proximity Read

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.Semantic proximity Read

The effect of single mutations in Zika virus envelope on escape from broadly neutralizing antibodiesSemantic proximity Read