Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of <i>Plasmodium falciparum</i>

Abstract excerpt

<h4>ABSTRACT</h4> Plasmodium falciparum requires a two-host system, moving between Anopheles mosquito and humans, to complete its life cycle. To overcome such dynamic growth conditions its histones undergo various post-translational modifications to up-regulate and down-regulate certain genes required for invasion and replication. The P. falciparum genome encodes six bromodomaincontaining proteins, of which Brom...

Topics

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• Histone Deacetylase Inhibitors Research
• HIV/AIDS drug development and treatment
• HIV Research and Treatment
• Malaria Research and Control
• Multiple Myeloma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

5b3849fa-af52-5dfd-9b70-d110e0889cbe

DOI

10.1101/2022.08.02.501158