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Deciphering divergent trypanosomatid nuclear complexes by analyzing interactomic datasets with AlphaFold2 and genetic approaches

2022-11-15

Abstract excerpt

Acetylation signaling pathways in trypanosomatids, a group of early branching organisms, are poorly understood due to highly divergent protein sequences. To overcome this challenge, we used interactomic datasets and AlphaFold2-multimer to predict direct interactions and validated them using yeast two and three-hybrid assays. We focused on MRG domain-containing proteins and their interactions, typically found in hi...

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Literature Corpus work
67dd35f0-ce76-533d-9835-6a3e9765242e
DOI
10.1101/2022.11.14.516520
Open publication

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Deciphering divergent trypanosomatid nuclear complexes by analyzing interactomic datasets with AlphaFold2 and genetic approachesDOI 10.1101/2022.11.14.516520
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