Article

LRRK2-G2019S couples metabolic stress to astrocytic senescence through DDB1-mediated p21 stabilization in Parkinson's disease

2026-07-14

Abstract excerpt

<title>Abstract</title> <p>Obesity and metabolic dysfunction are increasingly recognized as modifiers of Parkinson's disease (PD), yet the molecular mechanisms by which metabolic stress interacts with genetic susceptibility remain poorly understood. Here, we identify the PD-associated LRRK2-G2019S mutation as a molecular mediator that couples high-fat diet (HFD)-induced metabolic stress to astrocytic senescence a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94279539-1468-5e05-b8d3-c6beb70d745f
DOI: 10.21203/rs.3.rs-10289490/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LRRK2-G2019S couples metabolic stress to astrocytic senescence through DDB1-mediated p21 stabilization in Parkinson's diseaseDOI 10.21203/rs.3.rs-10289490/v1Read

Interaction of <i>G2019S LRRK2</i> and metabolic syndrome in a two-hit mouse model of Parkinson’s disease: LRRK2-driven systemic depletion of pyrimidine nucleosidesSemantic proximity Read

The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neuronsSemantic proximity Read

LRRK2 I1371V Impairs Astrocytic Glucose Metabolism and Triggers Multi-Organellar Dysfunction in PDSemantic proximity Read

LRRK2 I1371V Mutation Drives Astrocytic Glucose Metabolism Failure and Induces Integrated ER-Mitochondria-Lysosome Dysfunction in Parkinson's Disease.Semantic proximity Read

Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synucleinSemantic proximity Read

CPT1B-Mediated Fatty Acid Oxidation Induces Pigmentation in Solar LentigoSemantic proximity Read

The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons.Semantic proximity Read

Dysregulated mTOR-dependent signaling in neurodegeneration or carcinogenesis: implication for Alzheimer's disease and brain tumors.Semantic proximity Read

Chaperone-mediated Autophagy Deficiency Reprograms Cancer Metabolism Via TGFβ Signaling to drive Mesenchymal Tumor GrowthSemantic proximity Read

The Human LRRK2-R1441G Mutation Drives Age-Dependent Oxidative Stress and Mitochondrial Dysfunction in Dopaminergic NeuronsSemantic proximity Read

Precision metabolome reprogramming for imprecision therapeutics in retinitis pigmentosaSemantic proximity Read

DJ-1 mediates regulation of metabolism and immune response in Parkinson’s disease astrocytes and Glioblastoma cellsSemantic proximity Read