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Article

The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons.

Aging cell - 1 Apr 2024

Russo Taylor, Kolisnyk Benjamin, B S Aswathy, Plessis-Belair Jonathan, Kim Tae Wan, Martin Jacqueline, Ni Jason, Pearson Jordan A, Park Emily J, Sher Roger B, Studer Lorenz, Riessland Markus

Abstract excerpt

Idiopathic Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, which is associated with neuroinflammation and reactive gliosis. The underlying cause of PD and the concurrent neuroinflammation are not well understood. In this study, we utilize human and murine neuronal lines, stem cell-derived dopaminergic neurons, and mice to demonstrate that three...

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Source

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Identifiers

PMID: 38303548
DOI: 10.1111/acel.14077
PMCID: PMC11019121

Genes

SATB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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