Article

The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons

2023-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Idiopathic Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, which is associated with neuroinflammation and reactive gliosis. The underlying cause of PD and the concurrent neuroinflammation are not well understood. In this study, we utilized human and murine neuronal lines, stem cell–derived dopaminergic neurons, and mice to demo...

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Literature Corpus work: 41032e86-795c-57a9-b266-7c5cccb89659
DOI: 10.1101/2023.07.19.549710

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