Article
Dysregulated mTOR-dependent signaling in neurodegeneration or carcinogenesis: implication for Alzheimer's disease and brain tumors.
Journal of Alzheimer's disease : JAD - 1 Jan 2013
Wang Shan, Wu Jing, Nie Sheng-Dan, Bereczki Erika, Pei Jin-Jing
Abstract excerpt
Recent evidence implicated aberrant mammalian target of rapamycin (mTOR)-dependent signaling in both Alzheimer's disease (AD) and brain tumors. This review focuses on the potential mechanisms shared by both neurodegeneration and carcinogenesis. In particular, attention was paid to the possible roles of mTOR-dependent signaling in these two fundamental pathophysiological processes. We hypothesize that common...
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