Article

Chaperone-mediated Autophagy Deficiency Reprograms Cancer Metabolism Via TGFβ Signaling to drive Mesenchymal Tumor Growth

2022-07-07

Abstract excerpt

<h4>Summary</h4> The role of chaperone-mediated autophagy (CMA) in cancer initiation and progression is not well understood due to the lack of a loss-of-function cancer models of LAMP2A, the key regulator of this process. Here, by generating an isoform-specific knockout of LAMP2A, we show that CMA deficiency promotes proliferation and tumor growth in human cancers of mesenchymal origin. Accordingly, we observed t...

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Literature Corpus work: 8b036422-58f8-5840-8792-17569da7ab55
DOI: 10.1101/2022.07.07.499098

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