Article

ARF1 prevents aberrant type I IFN induction by regulating STING activation and recycling

2023-05-01

Abstract excerpt

<h4>ABSTRACT</h4> Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the endoplasmic reticulum (ER)-Golgi axis to induce IFN signalling. Termination is achieved through autophagic degradation or recycling of STING by retrograde Golgi-to-ER transport. Here, we identify the GTPase ARF1 as a cru...

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Literature Corpus work: bbc50be5-6d8f-5794-b4b5-ee63419b2cb2
DOI: 10.1101/2023.04.28.23289152

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