Article

GPR132 antagonists alleviate atherosclerosis in ApoE -/- mice by inhibiting M1 polarization of macrophages

2026-06-01

Abstract excerpt

<title>Abstract</title> <p> Background Atherosclerosis (AS) is a chronic inflammatory disorder with substantial global prevalence, wherein macrophage polarization and vascular smooth muscle cells (VSMCs) phenotypic switching are critical pathogenic events. Although G protein-coupled receptor 132 (GPR132) is markedly expressed in macrophages, its specific role and mechanism in AS-associated macrophage polarizati...

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Literature Corpus work: 940596e6-9095-5ddf-9f9f-9cac33cf0ba6
DOI: 10.21203/rs.3.rs-9525879/v1

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