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Article

Deletion of Myeloid GSK3α Attenuates Atherosclerosis and Promotes an M2 Macrophage Phenotype.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2015

McAlpine Cameron S, Huang Aric, Emdin Abby, Banko Nicole S, Beriault Daniel R, Shi Yuanyuan, Werstuck Geoff H

Abstract excerpt

OBJECTIVE: Glycogen synthase kinase (GSK)-3α/β has been implicated in the pathogenesis of diabetes mellitus, cancer, Alzheimer, and atherosclerosis. The tissue- and homolog-specific functions of GSK3α and β in atherosclerosis are unknown. This study examines the effect of hepatocyte or myeloid cell deletion of GSK3α or GSK3β on atherosclerosis in low-density lipoprotein receptor (LDLR)(-/-) mice. APPROACH AND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25767272
DOI: 10.1161/ATVBAHA.115.305438

Genes

LDLR
STAT3
STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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