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Article

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

2016-07-26

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals and is an important cause of arrhythmias and heart failure. Clinically, HCM is characterized as causing hyper-contractility, and therapies are aimed toward controlling the hyperactive physiology. β-cardiac myosin comprises ~40 percent of genetic mutations associated with HCM and the converter domain of myosin is a hot spot for HCM-causing mutations, bu...

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Literature Corpus work
fc442efe-5741-5a06-97eb-403ecd582a0f
DOI
10.1101/065649
Open publication

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Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathyDOI 10.1101/065649
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