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Article

Insights into human beta-cardiac myosin function from single molecule and single cell studies.

Journal of cardiovascular translational research - 1 Dec 2009

Sivaramakrishnan Sivaraj, Ashley Euan, Leinwand Leslie, Spudich James A

Abstract excerpt

beta-Cardiac myosin is a mechanoenzyme that converts the energy from ATP hydrolysis into a mechanical force that drives contractility in muscle. Thirty percent of the point mutations that result in hypertrophic cardiomyopathy are localized to MYH7, the gene encoding human beta-cardiac myosin heavy chain (beta-MyHC). Force generation by myosins requires a tight and highly conserved allosteric coupling between its...

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Share to Cardiomyopathy, Hypertrophic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomyopathy, Hypertrophic, Familial

Share to Genetic Predisposition to Disease

Share to Molecular Imaging

Share to Myocardial Contraction

Share to Myocytes, Cardiac

Share to Ventricular Myosins

Source

Open in PubMed Open full text

Identifiers

PMID: 20560001
DOI: 10.1007/s12265-009-9129-2
PMCID: PMC4342148

Genes

MYH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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