Article
Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor.
Circulation research - 20 Jul 2012
Moore Jeffrey R, Leinwand Leslie, Warshaw David M
Abstract excerpt
Hypertrophic (HCM) and dilated (DCM) cardiomyopathies are inherited diseases with a high incidence of death due to electric abnormalities or outflow tract obstruction. In many of the families afflicted with either disease, causative mutations have been identified in various sarcomeric proteins. In this review, we focus on mutations in the cardiac muscle molecular motor, myosin, and its associated light chains....
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