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SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci.

Briefings in bioinformatics - 22 Mar 2021

Goswami Pratik, Bartas Martin, Lexa Matej, Bohálová Natália, Volná Adriana, Červeň Jiří, Červeňová Veronika, Pečinka Petr, Špunda Vladimír, Fojta Miroslav, Brázda Václav

Abstract excerpt

SARS-CoV-2 is an intensively investigated virus from the order Nidovirales (Coronaviridae family) that causes COVID-19 disease in humans. Through enormous scientific effort, thousands of viral strains have been sequenced to date, thereby creating a strong background for deep bioinformatics studies of the SARS-CoV-2 genome. In this study, we inspected high-frequency mutations of SARS-CoV-2 and carried out...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33341900
DOI: 10.1093/bib/bbaa385
PMCID: PMC7799342

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