Article

Combining CRISPR/Cas9 mutagenesis and a small-molecule inhibitor to probe the function of MELK in cancer

2017-10-16

Abstract excerpt

The Maternal Embryonic Leucine Zipper Kinase (MELK) has been identified as a promising therapeutic target in multiple cancer types. MELK over-expression is associated with aggressive disease, and MELK has been implicated in numerous cancer-related processes, including chemotherapy resistance, stem cell renewal, and tumor growth. On the basis of these findings, a MELK inhibitor is currently being tested in several...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93ec0279-1564-5dd6-84a2-d1c4af867c83
DOI: 10.1101/203984

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combining CRISPR/Cas9 mutagenesis and a small-molecule inhibitor to probe the function of MELK in cancerDOI 10.1101/203984Read

Maternal Embryonic Leucine Zipper Kinase (MELK) in Cancer: Biological Functions, Therapeutic Potential, and ControversiesSemantic proximity Read

Maternal Embryonic Leucine Zipper Kinase: Key Kinase for Stem Cell Phenotype in Glioma and Other CancersSemantic proximity Read

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilitiesSemantic proximity Read

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.Semantic proximity Read

A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancersSemantic proximity Read

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.Semantic proximity Read

A novel tool for monitoring endogenous human MYC transcription and translation by EGFP tag insertion at the 3’ end using CRISPR-Cas9 genome editingSemantic proximity Read

CRISPR/Cas9 editing of the genome for cancer modeling.Semantic proximity Read

Application of CRISPR/Cas9 screening to study cancer drivers and to identify novel cancer vulnerabilitiesSemantic proximity Read

CRISPR Interference (CRISPRi) and CRISPR Activation (CRISPRa) to Explore the Oncogenic lncRNA Network.Semantic proximity Read

MELK Downregulation in NPCs Disrupts Cortical Neurogenesis via G2/M Dysregulation: Autism ImplicationsSemantic proximity Read

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethalitySemantic proximity Read