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A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers

2021-07-16

Abstract excerpt

Maternal embryonic leucine zipper kinase (MELK) is frequently overexpressed in cancer, but the role of MELK in cancer is still poorly understood. MELK was shown to have roles in many cancer-associated processes including tumor growth, chemotherapy resistance, and tumor recurrence. To determine whether the frequent overexpression of MELK can be exploited in therapy, we performed a high-throughput screen using a lib...

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Identifiers and source

Literature Corpus work
c3165a5e-9afc-57ee-b9a8-55a822970cab
DOI
10.1101/2021.07.16.452653
Open publication

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A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancersDOI 10.1101/2021.07.16.452653
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