Article

Polyamine dysregulation converges with RASopathies on RAS/MAPK and sensory processing phenotypes in <i>Drosophila</i>

2026-01-24

Abstract excerpt

<h4>ABSTRACT</h4> RASopathies are developmental conditions associated with cognitive and sensory processing impairments. They are caused by pathogenic variants in genes that result in overactivation of the RAS/MAPK signaling pathway. Genes linked to this pathway have been reported to be enriched among Drosophila models with habituation deficits, a behavioral phenotype reflecting sensory filtering. To identify hi...

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Literature Corpus work: 93dd9776-c40e-5446-a6ef-27899b465b78
DOI: 10.64898/2026.01.23.701032

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