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Article

Development and characterization of a Drosophila model of Snyder-Robinson syndrome.

Methods in enzymology - 1 Jan 2025

Tao Xianzun, Zhai R Grace

Abstract excerpt

Snyder-Robinson Syndrome (SRS) is an X-linked disorder characterized by intellectual disability, skeletal abnormalities, and immune system dysfunction. SRS is caused by mutations in the spermine synthase (SMS) gene, leading to polyamine dysregulation, and a myriad of cellular dysfunctions. This chapter presents a methodology for developing and characterizing a Drosophila model of SRS that recapitulates phenotypes...

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Identifiers

PMID: 40382141
DOI: 10.1016/bs.mie.2025.01.077
PMCID: PMC13196596

Genes

SMS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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