Article
Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA.
PLoS genetics - 1 May 2015
Schmid Tobias, Snoek L Basten, Fröhli Erika, van der Bent M Leontien, Kammenga Jan, Hajnal Alex
Abstract excerpt
Human cancer is caused by the interplay of mutations in oncogenes and tumor suppressor genes and inherited variations in cancer susceptibility genes. While many of the tumor initiating mutations are well characterized, the effect of genetic background variation on disease onset and progression is less understood. We have used C. elegans genetics to identify genetic modifiers of the oncogenic RAS/MAPK signaling...
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