Article

Integrative cross-species analyses identify deficits in habituation learning as a widely affected mechanism in Autism

2018-03-20

Abstract excerpt

<h4>Background</h4> Although habituation is one of the most ancient and fundamental forms of learning, its regulators and relevance for human disease are poorly understood. <h4>Methods</h4> We manipulated the orthologs of 286 genes implicated in intellectual disability (ID) with or without comorbid autism spectrum disorder (ASD) specifically in Drosophila neurons, and tested these models in light-off jump habit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10e8a7b2-f523-568a-a8dc-229bd68452f6
DOI: 10.1101/285981

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative cross-species analyses identify deficits in habituation learning as a widely affected mechanism in AutismDOI 10.1101/285981Read

Genetics, Molecular Control and Clinical Relevance of Habituation LearningSemantic proximity Read

Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation.Semantic proximity Read

Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes.Semantic proximity Read

Polyamine dysregulation converges with RASopathies on RAS/MAPK and sensory processing phenotypes in <i>Drosophila</i>Semantic proximity Read

Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene <i>DLG2</i>Semantic proximity Read

The Adaptor Protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windowsSemantic proximity Read

Insertion of rare autism variants in synaptic genes induce novel behavioral phenotypes in <i>C. elegans</i>Semantic proximity Read

Mechanisms of developmental regression in autism and the broader phenotype: a neural network modeling approach.Semantic proximity Read

<i>cacna2d3</i> , a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity thresholdSemantic proximity Read

Spatial and Temporal Gene Function Studies in Rodents: Towards Gene-Based Therapies for Autism Spectrum Disorder.Semantic proximity Read

Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links.Semantic proximity Read

Whole-brain clearing reveals region- and cell type-specific imbalances in inhibitory neurons in a mouse model for Kleefstra SyndromeSemantic proximity Read