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<i>Drosophila Prickle</i> Mutants Display Comorbid Neurological Phenotypes and Provide A Genetic Link Between Epilepsy and Autism Spectrum Disorder

2026-07-23

Abstract excerpt

Epilepsy affects approximately 30% of individuals with autism spectrum disorder (ASD). Consistent with these observations, while PRICKLE mutations are primarily linked with epilepsy, there is an enrichment of pathogenic DNA sequence variants in PRICKLE genes carried by individuals with ASD. Nonetheless, a connection between PRICKLE function and ASD warrants further investigation. Here, we show that a seizure-pr...

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Literature Corpus work
e654d1a0-7453-5b29-af3e-5b7a9857ced7
DOI
10.64898/2026.07.20.739611
Open publication

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<i>Drosophila Prickle</i> Mutants Display Comorbid Neurological Phenotypes and Provide A Genetic Link Between Epilepsy and Autism Spectrum DisorderDOI 10.64898/2026.07.20.739611
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