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Article

Distinct hyperactive RAS/MAPK alleles converge on common GABAergic interneuron core programs.

Development (Cambridge, England) - 15 May 2023

Knowles Sara J, Stafford April M, Zaman Tariq, Angara Kartik, Williams Michael R, Newbern Jason M, Vogt Daniel

Abstract excerpt

RAS/MAPK gene dysfunction underlies various cancers and neurocognitive disorders. Although the roles of RAS/MAPK genes have been well studied in cancer, less is known about their function during neurodevelopment. There are many genes that work in concert to regulate RAS/MAPK signaling, suggesting that if common brain phenotypes could be discovered they could have a broad impact on the many other disorders caused...

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Identifiers

PMID: 37254876
DOI: 10.1242/dev.201371
PMCID: PMC10281549

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