Article

p21 inhibitor UC2288 ameliorates MPTP induced Parkinson’s disease progression through inhibition of oxidative stress and neuroinflammation

2020-04-17

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Parkinson's disease (PD) is a neurodegenerative disease characterized by the early prominent death of dopaminergic neurons and a decrease of dopamine levels. Dopamine depletion leads to several motor dysfunctions, including resting tremor, muscular rigidity, bradykinesia and postural instability. Our previous study determined that knockout of parkin, a gene of PD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8623885a-bf9b-5bf2-9c0c-3f208af9809a
DOI: 10.21203/rs.3.rs-19130/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

p21 inhibitor UC2288 ameliorates MPTP induced Parkinson’s disease progression through inhibition of oxidative stress and neuroinflammationDOI 10.21203/rs.3.rs-19130/v1Read

Combined neuroprotective potential of Levodopa and Resveratrol to ameliorates cognitive impairments in rotenone-induced Parkinson's disease via targeting TLR mediated neuroinflammationSemantic proximity Read

Programmed Death-1 Deficiency Aggravates Motor Dysfunction In MPTP Model of Parkinson's Disease By Inducing Microglial Activation And Neuroinflammation In MiceSemantic proximity Read

Association of p53 with Neurodegeneration in Parkinson’s DiseaseSemantic proximity Read

Pharmacological Blocker of NF-κb and Mitochondrial Ros Restrict NLRP3 Inflammasome Activation and Rescue Dopaminergic Neurons in Vitro and in Vivo Parkinson’s DiseaseSemantic proximity Read

Evaluation of potential neuroprotective effects of Vanillin against MPP+/MPTP-induced dysregulation of dopaminergic regulatory mechanisms in SH-SY5Y cells and Parkinson's disease mice modelSemantic proximity Read

The potential applications of traditional Chinese medicine in Parkinson's disease: A new opportunitySemantic proximity Read

PD-1 Knockout Aggravates Motor Dysfunction In The MPTP Model of Parkinson's Disease By Inducing Microglial Activation And Neuroinflammation In MiceSemantic proximity Read

NOX2-Derived Hydrogen Peroxide Impedes the AMPK/Akt-mTOR Signaling Pathway in Parkinson's Disease in Vitro ModelsSemantic proximity Read

Evaluation of potential neuroprotective effects of Vanillin against MPP+/MPTP-induced dysregulation of dopaminergic regulatory mechanisms in SH-SY5Y cells and a mouse model of Parkinson's diseaseSemantic proximity Read

Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: Relevance to oxidative stress and neuroinflammation in Parkinson's diseaseSemantic proximity Read

Ceftriaxone affects ferroptosis and alleviates glial cell activation in Parkinson's diseaseSemantic proximity Read

Etiopathogenetic factors and neurobiological links between traumatic brain injury and Parkinson’s Disease: The Case of Muhammad AliSemantic proximity Read