Article

Morpheus-3D: Structural Diversity-Guided Detection and Localization of Protein Fold Switching

2026-08-19

Abstract excerpt

Proteins that reversibly adopt multiple stable folds challenge the classical sequence–structure paradigm, yet their discovery remains limited because fold switching is difficult to detect experimentally and current computational methods fail to resolve the underlying conformationally plastic regions. Here we present Morpheus-3D, a sequence-based framework that quantifies residue-level tertiary structural diversity...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a321d2d-b4ff-5b9f-8d92-883c2fa24923
DOI: 10.64898/2026.08.16.745091

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Morpheus-3D: Structural Diversity-Guided Detection and Localization of Protein Fold SwitchingDOI 10.64898/2026.08.16.745091Read

A sequence-based method for predicting extant fold switchers that undergo α-helix <-> β-strand transitionsSemantic proximity Read

Decoding conformational heterogeneity across disordered proteomesSemantic proximity Read

A method for predicting evolved fold switchers exclusively from their sequencesSemantic proximity Read

ProteinFlux: accurate, rapid and scalable generative prediction of protein dynamics driven by post-translational modificationsSemantic proximity Read

Rapid Evolutionary Dynamics of Structural Disorder as a Potential Driving Force for Biological Divergence in FlavivirusesSemantic proximity Read

diffBUM-HMM: a robust statistical modeling approach for detecting RNA flexibility changes in high-throughput structure probing data.Semantic proximity Read

Protein 3D structure computed from evolutionary sequence variation.Semantic proximity Read

Prediction of multiple conformational states by combining sequence clustering with AlphaFold2Semantic proximity Read

Conformational ensembles of the human intrinsically disordered proteome: Bridging chain compaction with function and sequence conservationSemantic proximity Read

Rules for designing protein fold switches and their implications for the folding codeSemantic proximity Read

EVOLVE: A Web Platform for Evolutionary Phase Analysis and New Variant Exploration from Multi-Sequence DataSemantic proximity Read

PLANET-MD: Ultra-fast Proteome-scale Prediction of Allosteric Networks in ProteinsSemantic proximity Read