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Article

MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Apr 2009

Adachi Megumi, Autry Anita E, Covington Herb E, Monteggia Lisa M

Abstract excerpt

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder that results from loss of function mutations in the methyl-CpG binding protein 2 (MECP2) gene. Using viral-mediated basolateral amygdala (BLA)-specific deletion of Mecp2 in mice, we show that intact Mecp2 function is required for normal anxiety behavior as well as some types of learning and memory. To examine whether these behavioral deficits are the...

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Source

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Identifiers

PMID: 19339616
DOI: 10.1523/JNEUROSCI.4225-08.2009
PMCID: PMC3005250

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome.PMID 19339616Read ↗

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