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Programming Brain Cell-Type-Selective Delivery In Vivo with Transporter-Guided Therapeutics

2026-06-18

Abstract excerpt

Many diseases arise from dysfunction of defined cell populations, yet most therapeutics distribute broadly, limiting efficacy and causing toxicity. We developed ExACT, a platform for cell-type-selective intracellular delivery that exploits membrane transporters. In vivo screening of combinatorial fluorescent small-molecule libraries in mouse brain identified chemistries whose uptake is dictated by endogenous trans...

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Literature Corpus work
939b689f-619c-5f0c-ba9b-5f0a70faeb70
DOI
10.64898/2026.06.14.732141
Open publication

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Programming Brain Cell-Type-Selective Delivery In Vivo with Transporter-Guided TherapeuticsDOI 10.64898/2026.06.14.732141
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