Article

Multi-omics of C9orf72 spinal cord organoids reveal convergent molecular signatures and targets

2026-07-08

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> amyotrophic lateral sclerosis is the most common adult-onset motor neuron disease, characterised by the progressive degeneration of upper and lower motor neurons in the brain and spinal cord. Despite substantial advances in the understanding of underlying disease mechanisms, effective therapies remain lacking. <bold>Methods:</bold> we generated spinal cord...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a6f3ebb-0945-59fb-b4f1-6b00dc38c475
DOI: 10.21203/rs.3.rs-10053820/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-omics of C9orf72 spinal cord organoids reveal convergent molecular signatures and targetsDOI 10.21203/rs.3.rs-10053820/v1Read

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patientsSemantic proximity Read

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patientsSemantic proximity Read

Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoidsSemantic proximity Read

Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosisSemantic proximity Read

Molecular Network Analysis Suggests a Logical Hypothesis for the Pathological Role of C9orf72 in Amyotrophic Lateral Sclerosis/Frontotemporal DementiaSemantic proximity Read

High content live profiling reveals concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosisSemantic proximity Read

Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTDSemantic proximity Read

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.Semantic proximity Read

Generation of <i>C9orf72</i> repeat knock-in iPSC lines for modelling ALS and FTDSemantic proximity Read

Meta-analysis of the amyotrophic lateral sclerosis spectrum uncovers genome instabilitySemantic proximity Read

CRISPR/Cas9-mediated generation of a <i>de novo C9ORF72</i> knock-in isogenic iPSC cell bank to model ALS and FTDSemantic proximity Read

Multi-regional transcriptomic profiling reveals divergent molecular mechanisms in ALS-related neurodegeneration.Semantic proximity Read