Article

Hexanucleotide repeat expansions in C9orf72 alter microglial responses and prevent a coordinated glial reaction in ALS

2022-10-26

Abstract excerpt

<title>Abstract</title> Neuroinflammation is an important hallmark in amyotrophic lateral sclerosis (ALS). Experimental evidence has highlighted a role of microglia in the modulation of motor neuron degeneration. However, the exact contribution of microglia to both sporadic and genetic forms of ALS is still unclear. We generated single nuclei profiles of spinal cord and motor cortex from sporadic and C9orf72 A...

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Literature Corpus work: f2590bfb-917b-56df-bf9f-3cc40aef10eb
DOI: 10.21203/rs.3.rs-2163908/v1

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