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Article

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2015

Sun Shuying, Sun Ying, Ling Shuo-Chien, Ferraiuolo Laura, McAlonis-Downes Melissa, Zou Yiyang, Drenner Kevin, Wang Yin, Ditsworth Dara, Tokunaga Seiya, Kopelevich Alex, Kaspar Brian K, Lagier-Tourenne Clotilde, Cleveland Don W

Abstract excerpt

Ubiquitous expression of amyotrophic lateral sclerosis (ALS)-causing mutations in superoxide dismutase 1 (SOD1) provokes noncell autonomous paralytic disease. By combining ribosome affinity purification and high-throughput sequencing, a cascade of mutant SOD1-dependent, cell type-specific changes are now identified. Initial mutant-dependent damage is restricted to motor neurons and includes synapse and metabolic...

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Identifiers

PMID: 26621731
DOI: 10.1073/pnas.1520639112
PMCID: PMC4687558

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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