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Article

Breaking the Mold: Transcription Factors in the Anucleate Platelet and Platelet-Derived Microparticles

13 Feb 2015

Abstract excerpt

Platelets are small anucleate blood cells derived from megakaryocytes. In addition to their pivotal roles in hemostasis, platelets are the smallest, yet most abundant, immune cells and regulate inflammation, immunity, and disease progression. Although platelets lack DNA, and thus no functional transcriptional activities, they are nonetheless rich sources of RNAs, possess an intact spliceosome, and are thus...

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PMID: 25762994
DOI: 10.3389/fimmu.2015.00048

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