Article
Change in protein phenotype without a nucleus: translational control in platelets.
Seminars in thrombosis and hemostasis - 1 Aug 2004
Weyrich Andrew S, Lindemann Stephan, Tolley Neal D, Kraiss Larry W, Dixon Dan A, Mahoney Tracey M, Prescott Stephen P, McIntyre Tom M, Zimmerman Guy A
Abstract excerpt
For most cells the nucleus takes center stage. Not only is it the largest organelle in eukaryotic cells, it carries most of the genome and transcription of DNA to RNA largely takes place in the nucleus. Because transcription is a major step in gene regulation, the absence of a nucleus is limiting from a biosynthetic standpoint. Consequently, the anucleate status of platelets has stereotyped it as a cell without...
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