Article

To generate functional anti-protease-activated receptor-4 (PAR4), a G protein-coupled receptor, antibodies through PAR4-mRNA-LNP immunization

2025-06-20

Abstract excerpt

<title>Abstract</title> <p> G protein-coupled receptors (GPCRs) are key therapeutic targets for various diseases, such as the thrombin receptor protease-activated receptor 4 (PAR4) in thrombotic cardiovascular disorders. The structural complexity of native GPCRs limits recombinant protein production. Traditional GPCR antibody development relies on GPCR peptide fragments for animal immunization. These peptides po...

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Literature Corpus work: 3ccebeb0-f3b8-5e1d-92e7-8ac48a1b7faa
DOI: 10.21203/rs.3.rs-6763159/v1

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