Article

Local Mitochondrial Physiology Defined by mtDNA Quality Guides Purifying Selection

2025-08-11

Abstract excerpt

The mitochondrial genome (mtDNA) encodes essential subunits of the electron transport chain and ATP synthase. Mutations in these genes impair oxidative phosphorylation, compromise mitochondrial ATP production and cellular energy supply, and can cause mitochondrial diseases. These consequences highlight the importance of mtDNA quality control (mtDNA-QC), the process by which cells selectively maintain intact mtDNA...

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Literature Corpus work: 93568ac5-5608-537f-8145-fb9e815d74bd
DOI: 10.1101/2025.08.08.669275

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